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KMID : 1161220230660100441
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Clinical and Experimental Pediatrics
2023 Volume.66 No. 10 p.441 ~ p.446
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Neonatal risk factors associated with attention-deficit/hyperactivity disorder: an umbrella review
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Ensiyeh Jenabi
To Hoai T. Nguyen
Sajjad Farashi
Saeid Bashirian
Kim Gwang-Sil
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Abstract
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Background : Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is being encountered more frequently.
Purpose : In this study, by compiling the evidence from available meta-analyses, an umbrella systematic review was performed of the neonatal risk factors associated with ADHD.
Methods : The PubMed, Scopus, and Web of Science databases were searched for eligible studies. Only systematic reviews were included. Using a random-effects model, 95% prediction intervals were reported for each risk factor. Three studies were ultimately included in the review.
Results : Congenital heart disease, short-duration or incomplete breastfeeding, low birth weight, and 5-minute Apgar scores <7 were significant risk factors for ADHD. However, the quality of the included systematic reviews was low to moderate and the evidence credibility level was suggestive to weak.
Conclusion : The results of this umbrella review proposed that congenital anomalies, short-duration or incomplete breastfeeding, low birth weight, and low Apgar scores were important factors for the manifestation of ADHD symptoms. However, the inclusion of more high-quality studies is needed to validate our results.
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KEYWORD
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Attention deficit disorder with hyperactivity, Neonatal, Risk factors, Umbrella review
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